Open AccessTotal Phenytoin concentration is not well correlated with active free drug in critically-ill head trauma patients
Author(s) -
Kourosh Sadeghi,
Farin Hadi,
Arezoo Ahmadi,
Hadi Hamishehkar,
MohammadTaghi Beigmohammadi,
Ata Mahmoodpoor,
Mohammad Reza Rouini,
Shirin Farhudi,
Narjes Hendoui,
Atabak Najafi,
Mojtaba Mojtahedzadeh
Publication year - 2013
Publication title -
journal of research in pharmacy practice
Language(s) - English
Resource type - Journals
eISSN - 2319-9644
pISSN - 2279-042X
DOI - 10.4103/2279-042x.122376
Subject(s) - phenytoin , medicine , anesthesia , critically ill , pharmacokinetics , therapeutic drug monitoring , mechanical ventilation , head trauma , hypoalbuminemia , drug , therapeutic index , pharmacology , surgery , epilepsy , psychiatry
Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. Phenytoin has a complex pharmacokinetics and monitoring of its serum concentrations is recommended during treatment. Total phenytoin concentration is routinely measured for monitoring of therapy. In this study, we evaluated the correlation between phenytoin total and free concentrations in neurotrauma critically-ill patients to determine whether the phenytoin total concentration is a reliable predictor of free drug, which is responsible for the therapeutic effects.