Open AccessVascular endothelial growth factor expression in ovarian serous carcinomas and its effect on tumor proliferation
Author(s) -
Gayatri Ravikumar,
Julian Crasta
Publication year - 2013
Publication title -
south asian journal of cancer
Language(s) - English
Resource type - Journals
eISSN - 2278-4306
pISSN - 2278-330X
DOI - 10.4103/2278-330x.110503
Subject(s) - medicine , immunohistochemistry , vascular endothelial growth factor , serous fluid , autocrine signalling , paracrine signalling , pathology , vegf receptors , receptor
Vascular endothelial growth factor (VEGF), an endothelial mitogen, acts through VEGF receptors (VEGFRs) on the endothelial cells. During neoplastic transformation, it is hypothesized that the tumor expresses VEGF and also acquire VEGF receptor, enabling VEGF action in an autocrine and paracrine manner with varied effects on the tumor growth and progression. This study on ovarian serous carcinomas (OSCs) was done to determine the expression of VEGF and to correlate it with tumor proliferation.