Open AccessNot all elevated hormones are toxic: A case of thyroid hormone resistance
Author(s) -
Rajeev Philip,
Mohan Krishnakumar Padikal,
Altaf Alinausad,
Charamelsankaran Keshavan
Publication year - 2016
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/2249-4863.192339
Subject(s) - medicine , hormone , thyroid , endocrinology , thyroid function tests , thyroid hormone receptor
Resistance to thyroid hormone syndrome (RTH) is a rare disorder and is usually inherited as dominantly negative autosomal trait. RTH is caused by mutations in the thyroid hormone receptor beta. Patients with RTH usually do not have signs and symptoms of thyrotoxicosis, but the thyroid function test shows an elevated T3 and T4, which get misinterpreted as hyperthyroidism, resulting in unnecessary treatment.