Open AccessMononucleosis-like drug rash: An interesting case presentation
Author(s) -
Reshma T Vishnani,
Ram H Malkani,
Afsha A Topal,
Desai Hg
Publication year - 2014
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/2249-4863.130329
Subject(s) - medicine , dapsone , rash , mononucleosis , nausea , vomiting , jaundice , dermatology , pediatrics , drug , differential diagnosis , adverse effect , surgery , immunology , psychiatry , virus , pathology
Dapsone hypersensitivity syndrome (DHS) is a rare adverse effect of the commonly prescribed drug dapsone. We present a case of a 35-year-old male who was referred to us from the gastroenterologist with complaints of rash, nausea, vomiting, and jaundice since 2 days with a provisional differential diagnosis of infectious mononucleosis or viral exanthema. On enquiry patient gave history of taking dapsone a week prior for refractory urticaria. After thorough investigations we diagnosed him with DHS. This syndrome occurs in a relatively small proportion of patients, but it is associated with considerable morbidity and mortality. The reason for presenting this case is to remind physicians of the unpredictability and potential severity of this reaction which makes it a major concern in clinical practice.