Open AccessA review on mucoadhesive polymer used in nasal drug delivery system
Author(s) -
Mayank Chaturvedi,
Manish Kumar,
Kamla Pathak
Publication year - 2011
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/2231-4040.90876
Subject(s) - drug delivery , nasal administration , nasal cavity , dosage form , mucoadhesion , mucous membrane of nose , first pass effect , delivery system , prodrug , drug , pharmacology , in vivo , liposome , biomedical engineering , drug carrier , medicine , chemistry , nanotechnology , materials science , surgery , biology , pathology , microbiology and biotechnology
This update review is on mucoadhesive polymers used in nasal dosage forms. The nasal mucosa provides a potentially good route for systemic drug delivery. One of the most important features of the nasal route is that it avoids first-pass hepatic metabolism, thereby reducing metabolism. The application of mucoadhesive polymers in nasal drug delivery systems has gained to promote dosage form residence time in the nasal cavity as well as improving intimacy of contact with absorptive membranes of the biological system. The various new technology uses in development of nasal drug delivery dosage forms are discussed. The various dosage forms are vesicular carriers (liposome, noisome), nanostructured particles, prodrugs, in situ gelling system with special attention to in vivo studies.