Open AccessA study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy
Author(s) -
Liana S. Usmanova,
Марат А. Зиганшин,
Valery V. Gorbatchuk,
S. A. Ziganshina,
D. A. Bizyaev,
А. А. Бухараев,
Timur A. Mukhametzyanov,
Alexander V. Gerasimov
Publication year - 2017
Publication title -
journal of advanced pharmaceutical technology and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
eISSN - 2231-4040
pISSN - 0976-2094
DOI - 10.4103/2231-4040.197331
Subject(s) - solubility , phenacetin , polyethylene glycol , dispersion (optics) , drug delivery , nanoparticle , superparamagnetism , chemical engineering , chemistry , magnetic nanoparticles , materials science , nanotechnology , chromatography , organic chemistry , magnetic field , magnetization , physics , engineering , quantum mechanics , optics
A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility. In this work, the distribution of superparamagnetic nanoparticles in the solid dispersion of polyethylene glycol with average molecular weight 950-1050 g/mol and phenacetin was studied using atomic force and magnetic force microscopy. The distribution of nanoparticles was found to be uniform in studied composites. Magnetically active solid dispersions may find application in the production of the capsulated drug delivery systems with enhanced solubility parameters.