Open AccessFormulation and optimization of mucoadhesive bilayer buccal tablets of atenolol using simplex design method
Author(s) -
SB Shirsand,
Sarasija Suresh,
GG Keshavshetti,
P. V. Swamy,
P. Vijay Prakash Reddy
Publication year - 2012
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.96924
Subject(s) - atenolol , buccal administration , bioavailability , bilayer , excipient , materials science , mucoadhesion , matrix (chemical analysis) , chromatography , mannitol , chemistry , pharmacology , drug delivery , nanotechnology , drug carrier , organic chemistry , membrane , medicine , biochemistry , blood pressure , radiology
In the present study, mucoadhesive buccal bilayer tablets of atenolol were fabricated with the objective of avoiding first pass metabolism and to improve its bioavailability with reduction in dosing frequency. Hence, the aim of this work was to design oral controlled release mucoadhesive tablets of atenolol and to optimize the drug release profile and bioadhesion.