Open AccessDevelopment and characterization of chronomodulated drug delivery system of captopril
Author(s) -
Archana S. Patil,
Panchaxari Mallappa Dandagi,
Vinayak S Masthiholimath,
Anand Panchakshari Gadad,
Basavaraj K Najwade
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.93010
Subject(s) - captopril , drug , drug delivery , computer science , pharmacology , medicine , materials science , nanotechnology , blood pressure
Hypertension shows circadian rhythm that there is a rise in pressure from the time of waking or before (about 4 to 8 a.m.), in most people. Conventional drug delivery system of captopril is inappropriate for the delivery of drug, as they cannot be administered just before the symptoms are worsened, because during this time the patients are asleep, bedtime dosing of captopril will not provide a therapeutic plasma drug concentration at the early hours of morning because of poor pharmacokinetic profile and shorter half-life of 1.9 hours. Thus, this study attempts to design and evaluate a chronomodulated pulsatile drug delivery system of captopril which was aimed to release the drug after a lag time of 6 hours.