Open AccessFormulation development and investigation of domperidone transdermal patches
Author(s) -
Prabhakar Prabhu,
Samip Shah,
Shankar Gundad
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.93008
Subject(s) - ethyl cellulose , bioavailability , transdermal , domperidone , absorption (acoustics) , dosage form , chemistry , methyl cellulose , folding endurance , drug , vinyl alcohol , chromatography , pharmacokinetics , materials science , polymer , pharmacology , cellulose , organic chemistry , dopamine , medicine , composite material , endocrinology
Domperidone is a dopamine antagonist with antiemetic properties having a plasma half life of 7-9 h with 15% oral bioavailability. In the present work transdermal patches of domperidone were prepared with the objective to improve its therapeutic efficacy, patient compliance and to reduce the frequency of dosing and side effects, as well as to avoid its extensive first pass metabolism of the drug.