Open AccessFormulation and evaluation of mixed matrix gastro-retentive drug delivery for famotidine
Author(s) -
Dasharath M. Patel,
Mehul J Patel,
Ajay M. Patel,
Chhagan N. Patel
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.93006
Subject(s) - friability , famotidine , dissolution , granulation , materials science , chromatography , factorial experiment , solubility , chemistry , mathematics , composite material , polymer , organic chemistry , pharmacology , medicine , statistics , ethyl cellulose
Present investigation describes an influence of ratio of Gelucire 43/01(hydrophobic) to hydroxypropyl methylcellulose K4M (HPMC K4M) (hydrophilic) and different fillers on release of famotidine from gastro-retentive tablets using 3(2) full factorial design. Ratio of Gelucire 43/01 to HPMC K4M (X(1)) and the type of filler (X(2)) were selected as independent variables while buoyancy lag time (BLT), drug release at 1h (Q(1)), 6h (Q(6)), and the 12h (Q(12)) were selected as dependent variables.