Open AccessStatistical optimization of floating pulsatile drug delivery system for chronotherapy of hypertension
Author(s) -
Sanjay J. Kshirsagar,
Shrikant V Patil,
Mangesh R. Bhalekar
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.93005
Subject(s) - pulsatile flow , factorial experiment , drug delivery , materials science , biomedical engineering , design–expert , sodium bicarbonate , chromatography , response surface methodology , chemical engineering , chemistry , mathematics , nanotechnology , medicine , statistics , engineering , cardiology
A pulsatile drug delivery system is characterized by a lag time that is an interval of no drug release followed by rapid drug release. The purpose of this work was to develop hollow calcium alginate beads for floating pulsatile release of valsartan intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release.