Open AccessDesign and evaluation of colon targeted modified pulsincap delivery of 5-fluorouracil according to circadian rhythm
Author(s) -
Dasharath M. Patel,
Rushiraj Jani,
Chhagan N. Patel
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.85969
Subject(s) - factorial experiment , capsule , dissolution , chemistry , chromatography , materials science , mathematics , biology , organic chemistry , statistics , botany
A modified pulsincap dosage form of 5-fluorouracil was developed to target drug to colorectal carcinoma according to daily oscillations of rate-limiting metabolizing enzyme dihydropyrimidine dehydrogenase.