Open AccessFormulation development and in vitro evaluation of gastroretentive hollow microspheres of famotidine
Author(s) -
Mayur A Chordiya,
Hemant H Gangurde,
K. Senthilkumaran,
Lokesh P. Kothari
Publication year - 2011
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.82423
Subject(s) - bioavailability , famotidine , materials science , drug delivery , ethyl cellulose , absorption (acoustics) , particle size , biomedical engineering , drug , dosage form , chromatography , emulsion , polymer , chemistry , nanotechnology , pharmacology , organic chemistry , composite material , medicine
The main aim of this study was to develop a gastroretentive, multiple-unit floating drug delivery system for a drug which is poorly absorbed from the lower gastrointestinal tract. Such a dosage form may provide an extended retention of drug in the upper gastrointestinal tract resulting in enhanced absorption and improved bioavailability.