Open AccessFormulation and development of plasma volume expander using natural and modified starch from Solanum tuberosum
Author(s) -
Nilima A. Thombre,
Ajit V Vishwakarma,
Trupti S Jadhav,
Kshirsagar Sanjay
Publication year - 2016
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.195930
Subject(s) - starch , hydroxyethyl starch , amylopectin , chemistry , osmotic pressure , polysaccharide , chromatography , biochemistry , amylose
To formulation and development of plasma volume expander (PVE) by using natural and modified starch from Solanum tuberosum . The function of blood circulation is to provide the needs of the body tissues and to maintain an appropriate environment in all tissue fluids of the body for the optimal survival and functions of the cells. Rapid restoration of the blood volume is necessary to decrease reduction in the amount of the blood. The PVEs are isotonic colloidal solutions, act by increasing the osmotic pressure of the intravascular compartment, which leads to the influx of the interstitial fluids through the capillary pore which, in turn, leads to the increase in the volume of the blood. Therefore, there is a need to discover the PVE with less side effects. The main aim of the present study is to use amylopectin as PVEs, fractionated from natural and modified starch obtained from S. tuberosum .