Open AccessColon specific drug delivery of tramadol HCl for chronotherapeutics of arthritis
Author(s) -
Rajyalakshmi Kadiyam,
Y. Indira Muzib
Publication year - 2015
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.147232
Subject(s) - friability , granulation , tramadol , chemistry , pharmacology , in vivo , tramadol hydrochloride , matrix (chemical analysis) , drug , drug delivery , chromatography , analgesic , materials science , medicine , first pass effect , microbiology and biotechnology , composite material , organic chemistry , biology
The objective of present work is to develop and evaluate a matrix system for Chronotherapeutic delivery of centrally acting of opioid analgesic (tramadol HCl) to treat nocturnal symptoms of arthritis using almond gum as carrier.