Open AccessDesign, formulation, and evaluation of novel sustain release bioadhesive in-situ gelling ocular inserts of ketorolac tromethamine
Author(s) -
Jayesh K Jethava,
Gaurang K Jethava
Publication year - 2014
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.143131
Subject(s) - bioadhesive , materials science , ketorolac tromethamine , chitosan , biomedical engineering , ultimate tensile strength , drug delivery , chromatography , ketorolac , composite material , chemistry , pharmacology , nanotechnology , medicine , organic chemistry , analgesic
The eye is an interesting organ. The tear flow and blinking reflex maintains a good environment and removes foreign material from the eye. Several polymeric systems have been used to fabricate ocular inserts for better ocular bioavailability and retention to drug of which gelling systems have shown advantages of convenient administration and increased contact time.