Open AccessNovel sustained release and swellable gastroretentive dosage form for ciprofloxacin hydrochloride
Author(s) -
Vinayak Dasharath Gaikwad,
Vishal Yadav,
Manish Dhananjay Gaikwad
Publication year - 2014
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.133057
Subject(s) - ciprofloxacin hydrochloride , dosage form , magnesium stearate , swelling , sodium bicarbonate , granulation , chromatography , materials science , matrix (chemical analysis) , chemistry , biomedical engineering , ciprofloxacin , composite material , antibiotics , organic chemistry , medicine , biochemistry
The present study aims at developing a gastroretentive swellable and floating matrix tablet formulation of ciprofloxacin hydrochloride (HCl) for the effective treatment of infections caused by susceptible organisms. Ciprofloxacin HCl is a fluoroquinoline antibiotic drug. Ciprofloxacin HCl is more stable in acidic medium and it has a narrow absorption window which is sited at the stomach and proximal portions of the small intestine, so it covers the required criteria for selection of drug for gastroretentive dosage form.