Open AccessDevelopment and evaluation of 6-mercaptopurine and metoclopramide polypill formulation for oral administration: In-vitro and ex vivo studies
Author(s) -
Rajani Chowdhary,
Roopa S Pai,
Gurinder Singh
Publication year - 2013
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.121306
Subject(s) - friability , metoclopramide , mucoadhesion , pharmacology , dosage form , granulation , magnesium stearate , chemistry , chromatography , ex vivo , bioavailability , first pass effect , materials science , medicine , drug , drug carrier , surgery , in vitro , biochemistry , composite material , vomiting
The present investigation was to develop a polypill of 6-mercaptopurine and metoclopramide. A polypill with delayed release granules of an anticancer and immediate release mucoadhesive tablet of antiemetic may result in the reduction of emesis caused by oral chemotherapy.