Open AccessSelf micro-emulsifying drug delivery system of tacrolimus: Formulation, in vitro evaluation and stability studies
Author(s) -
Parind Patel,
Hitesh Patel,
Shital S. Panchal,
Tejal Mehta
Publication year - 2013
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.114899
Subject(s) - differential scanning calorimetry , solubility , materials science , polyethylene glycol , chromatography , fourier transform infrared spectroscopy , pulmonary surfactant , particle size , tacrolimus , dissolution , drug delivery , chemistry , chemical engineering , organic chemistry , nanotechnology , medicine , biochemistry , physics , surgery , transplantation , engineering , thermodynamics
Tacrolimus has poor solubility in water ranging from 4 to 12 μg/mL. The oral bio availabilities of tacrolimus is poor and exhibits high intra and inter-subject variability (4-89%, average 25%) in the liver and the kidney transplant recipients and in patients with renal impairment.