Open AccessFormulation and characterization of ketoprofen liquisolid compacts by Box-Behnken design
Author(s) -
G. Vijayaranga Vittal,
R. Deveswaran,
Bharath Srinivasan,
B. V. Basavaraj,
V. Madhavan
Publication year - 2012
Publication title -
international journal of pharmaceutical investigation
Language(s) - English
Resource type - Journals
eISSN - 2230-973X
pISSN - 2230-9713
DOI - 10.4103/2230-973x.104398
Subject(s) - friability , box–behnken design , materials science , microcrystalline cellulose , differential scanning calorimetry , dissolution , angle of repose , ketoprofen , fourier transform infrared spectroscopy , chemical engineering , coating , factorial experiment , chromatography , composite material , ethyl cellulose , response surface methodology , cellulose , chemistry , polymer , mathematics , physics , statistics , engineering , thermodynamics
Liquisolid technique is used in delivery of lipophilic and poorly water soluble drugs through oral route. It involves dissolving water insoluble drugs in nonvolatile solvents and converting into acceptably flowing and compressible powders. The objective of the present work was to enhance the dissolution rate of ketoprofen using microcrystalline cellulose as carrier, aerosil 200 as coating material, and polyethylene glycol as nonvolatile water miscible liquid vehicle.