Open AccessDysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature
Author(s) -
Sunil Kumar Kota,
Kotni Gayatri,
Jaya Prakash Pani,
Siva Krishna Kota,
Lalit Kumar Meher,
Kirtikumar D Modi
Publication year - 2012
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.95706
Subject(s) - dysgerminoma , medicine , girl , turner syndrome , ovary , abdominal mass , gynecology , biopsy , gonadoblastoma , oophorectomy , karyotype , pathology , pediatrics , chromosome , hysterectomy , biology , genetics , gene
We report a 17-year-old girl evaluated for primary amenorrhea. Cytogenetic analysis of the peripheral blood lymphocytes revealed normal autosomes with 46X inv (Y) confirming the diagnosis of Turner's syndrome with Y cell line. Treatment was initiated with conjugated estrogen while recommending bilateral prophylactic oophorectomy to the patient. One year later the patient presented with abdominal mass, biopsy of the specimen following resection confirmed dysgerminoma originating from right ovary with no invasion or metastasis. The literature is reviewed with regard to the various pathogenetic mechanisms proposed for the development of germ cell tumors in ovary, the cytogenetic findings and recommendations to handle such scenario.