Open AccessCushing′s syndrome: Stepwise approach to diagnosis
Author(s) -
Anurag Lila,
Vijaya Sarathi,
Varsha S. Jagtap,
Tushar Bandgar,
P. S. N. Me,
Nalini Shah
Publication year - 2011
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.86974
Subject(s) - medicine , subclinical infection , dexamethasone , pediatrics , population , urine , intensive care medicine , environmental health
The projected prevalence of Cushing's syndrome (CS) inclusive of subclinical cases in the adult population ranges from 0.2-2% and it may no longer be considered as an orphan disease (2-3 cases/million/year). The recognition of CS by physicians is important for early diagnosis and treatment. Late-night salivary cortisol, dexamethasone suppressiontesti, or 24-h urine free cortisol are good screening tests. Positively screened cases need stepwise evaluation by an endocrinologist. This paper discusses the importance of screening for CS and suggests a stepwise diagnostic approach to a case of suspected hypercortisolism.