Open AccessAldose reductase (-106) C/T gene polymorphism and possibility of macrovascular complications in Egyptian type 2 diabetic patients
Author(s) -
Azhar Mohamed Nomair,
Mona Kamal Eldeeb,
Dalia Aly Maharem
Publication year - 2016
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.190549
Subject(s) - aldose reductase , medicine , type 2 diabetes , polymorphism (computer science) , gene , bioinformatics , endocrinology , genetics , diabetes mellitus , genotype , biology
Over the past three decades, the number of people with diabetes mellitus (DM) has more than doubled globally, making it one of the most important public health challenges to all nations. Aldose reductase (AR) is a rate-limiting enzyme in the polyol pathway, which has been implicated in the pathogenesis of diabetic microvascular complications; however, the association of the AR gene with diabetic macrovascular complications has rarely been investigated.