Open AccessEffect of steroid replacement on thyroid function and thyroid autoimmunity in Addison′ s disease with primary hypothyroidism
Author(s) -
Jaya Prakash Sahoo,
Jayakumar Selviambigapathy,
Sadishkumar Kamalanathan,
Krishnan Nagarajan,
Muthupillai Vivekanandan
Publication year - 2016
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.176356
Subject(s) - medicine , endocrinology , thyroid function tests , addison's disease , thyroid , thyroiditis , thyroid function , autoimmunity , subclinical infection , disease
Steroid replacement without thyroxine supplementation normalizes thyroid function test (TFT) in some but not all Addison's disease patients with primary hypothyroidism. Both autoimmune and nonautoimmune mechanisms contribute to this improvement in TFT. However, the documentation of the change in thyroid autoimmunity after cortisol replacement is very limited in the literature. The aim of this study was to determine the effect of steroid replacement on TFT and anti-thyroid peroxidase antibody (anti-TPO-Ab) titer in Addison's disease with primary hypothyroidism.