Open AccessAldose reductase C-106T gene polymorphism in type 2 diabetics with microangiopathy in Iranian individuals
Author(s) -
Majid Reza Sheikh Rezaee,
Ahmad Ahmadzadeh Amiri,
Mohammad Bagher HashemiSoteh,
Fatemeh Daneshvar,
Roghaye Emady-Jamaly,
Reza Jafari,
B Soleimani,
Hamed HaghiAminjan
Publication year - 2015
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.131762
Subject(s) - microangiopathy , medicine , aldose reductase , diabetic retinopathy , diabetic nephropathy , retinopathy , genotyping , diabetes mellitus , genotype , type 2 diabetes , endocrinology , nephropathy , gastroenterology , gene , genetics , biology
Aldose reductase (AR) is the rate-limiting enzyme in the glucose metabolism, which has been implicated in the pathogenesis of diabetic microvascular complications (MVCs). Frequent C-106T polymorphism in the promoter of the AR gene may change the expression of the gene.