Open AccessSpinal polyostotic fibrous dysplasia in two adults: Does only biopsy unravel the mystery?
Author(s) -
Abhay Gundgurthi,
MK Garg,
Rajinder Bhardwaj,
Simmi Kharb,
Aditi Pandit,
K. S. Brar,
Ravi Kumar,
Aditi Pandit
Publication year - 2013
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.122641
Subject(s) - polyostotic fibrous dysplasia , medicine , gnas complex locus , fibrous dysplasia , mccune–albright syndrome , biopsy , pathology , radiology , gene , biology , genetics , hormone , precocious puberty
Polyostotic fibrous dysplasia is a rare non-inheritable genetic disease due to mutation in GNAS gene. Here we present two adults who were accidentally detected lytic lesions in spine and after extensive evaluation for malignancies; was diagnosed on biopsy. Current concept of the disease and management is discussed.