Open AccessTwo unusual cases of severe recalcitrant hypocalcemia due to aminoglycoside-induced hypomagnesemia
Author(s) -
Tarun Varma,
Ashish Saini,
Roopal Panchani,
Nitin Gupta
Publication year - 2013
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.119573
Subject(s) - hypomagnesemia , medicine , aminoglycoside , fanconi syndrome , renal tubular acidosis , amikacin , kanamycin , nephrotoxicity , toxicity , antibiotics , pediatrics , acidosis , kidney , magnesium , materials science , biology , microbiology and biotechnology , metallurgy
Aminoglycoside (AMG)-induced renal toxicity is well-known and may manifest with non-oliguric renal failure or renal tubular dysfunction like Fanconi-like syndrome, Barter syndrome-like syndrome or distal renal tubular acidosis (RTA). These phenomena have been described with Gentamycin and Amikacin though rarely with Kanamycin. We present two cases of pulmonary tuberculosis that were treated with Kanamycin and during the course of treatment, developed severe recalcitrant hypocalcemia along with hypomagnesemia.