Open AccessPituitary oncocytoma presenting as Cushing′s disease
Author(s) -
MK Garg,
Reena Bharwaj,
Harish Pathak,
Simmi Kharb,
Abhay Gundgurthi,
Aditi Pandit,
K. S. Brar
Publication year - 2013
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.113778
Subject(s) - chromogranin a , medicine , synaptophysin , oncocytoma , immunohistochemistry , pathology , prolactin , cushing disease , cushing syndrome , hormone
A 19-year-old girl presented with classical features of Cushing's syndrome. Endocrinal evaluation was consistent with pituitary source of ACTH; but imaging showed normal pituitary. Bilateral inferior petrosal sinus sampling confirmed the diagnosis. A successful remission was achieved after adenomectomy by transphenoidal route. Histopathological examination was consistent with pituitary oncocytoma and immunohistochemistry was positive for synaptophysin, chromogranin, neuron specific enolase, S-100, ACTH, prolactin, and GH.