Open AccessOvarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl
Author(s) -
Sunil Kumar Kota,
Kotni Gayatri,
Jaya Prakash Pani,
Lalit Kumar Meher,
Siva Krishna Kota,
Kirtikumar D Modi
Publication year - 2012
Publication title -
indian journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 28
eISSN - 2230-9500
pISSN - 2230-8210
DOI - 10.4103/2230-8210.100658
Subject(s) - virilization , primary amenorrhea , girl , medicine , presentation (obstetrics) , amenorrhea , case presentation , gynecology , endocrinology , obstetrics , surgery , hormone , pregnancy , androgen , biology , developmental psychology , psychology , genetics
A 16-year-old girl presented with primary amenorrhea and excess hair growth on her body and face for the last three years, along with pain and a mass in her lower abdomen for last one year. Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation. Serum testosterone was 320 ng / dl and ultrasonogram of the pelvis revealed a solid mass of 5 × 4 cm in the left adnexa. Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone. Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary. Postoperatively the serum testosterone returned to 40 ng / dl and her menstrual cycle started after two months of surgery.