Open AccessAn unusual case of dapsone syndrome
Author(s) -
Mary Grace
Publication year - 2011
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.85999
Subject(s) - dapsone , medicine , pancytopenia , dermatology , rash , erythroderma , hepatosplenomegaly , leprosy , thalidomide , exfoliative dermatitis , hypersensitivity reaction , bone marrow , immunology , pathology , multiple myeloma , disease
Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report an unusual case of dapsone hypersensitivity, manifesting as bone marrow suppression and peripheral pancytopenia in addition to fever, rash, and hepatosplenomegaly.