Open AccessDarier-White disease in siblings responding to isotretinoin
Author(s) -
Ramesh M Bhat,
Krithi Raviraj Ullal,
Anita C Pinto,
D Sukumar
Publication year - 2010
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.73252
Subject(s) - darier's disease , medicine , darier disease , dermatology , isotretinoin , disease , dyskeratosis , keratosis , white (mutation) , keratoderma , epidermis (zoology) , xeroderma pigmentosum , mucous membrane , hyperkeratosis , pathology , genetics , gene , biology , anatomy , acne , dna repair
Darier-White disease (keratosis follicularis) is a rare disorder of keratinization involving the epidermis, mucous membranes, and nails. It is said to occur as a result of mutation in the ATP2A2 gene located on chromosome 12q23-24.1. In this article we present the case of two brothers with exacerbations of Darier-White disease who responded very well to systemic retinoids without any side effects within 2 weeks of commencing treatment.