Open AccessClear cell sarcoma
Author(s) -
Pınar Özuğuz,
Mukadder Koçak,
Pınar Atasoy,
İbrahim Vargel,
Tarık Çavuşoğlu
Publication year - 2014
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.142515
Subject(s) - medicine , neural crest , soft tissue , fibrosarcoma , clear cell sarcoma , melanoma , immunohistochemistry , lesion , pathology , sarcoma , soft tissue sarcoma , differential diagnosis , cancer research , biology , microbiology and biotechnology , embryo
Malignant melanoma (MM) of soft tissue, also called clear cell sarcoma (CCS) of tendons and aponeuroses, derives from the neural crest. CCS is similar morphologically to MM but has no precursor skin lesion, and instead, has a characteristic chromosomal translocation. Prognosis is related to the tumor size. Early recognition and initial radical surgery is the key to a favorable outcome. The tumor has to be differentiated from other benign and malignant lesions of the soft tissues, such as fibrosarcoma. The demonstration of melanin and a positive immunohistochemical reaction for S-100 protein and HMB-45 can assist in the differential diagnosis. We report the case of a 58-year-old woman with CCS arising from the soft tissue of her little finger.