Open AccessMultiple keratoacanthomas developing in healing plaques of Psoriasis
Author(s) -
Vineet Relhan,
Surabhi Sinha,
Nita Khurana,
Vijay Kumar Garg
Publication year - 2013
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.115517
Subject(s) - medicine , psoriasis , histopathology , keratoacanthoma , methotrexate , dermatology , lesion , skin lesion , pathology , surgery , basal cell
A 22 year old male psoriatic patient presented with multiple reddish scaly plaques all over body. After hematological and biochemical investigations the patient was started on oral methotrexate 15 mg weekly. PASI score at the start of treatment was 26.2. After 3 months PASI dropped to 11.5, the dose of methotrexate was tapered to 7.5mg weekly and the patient was maintained on this dose and kept under monthly follow up. Four months later, the patient presented with reddish to hyperpigmented raised firm nodules having a central crater over the healing plaques of psoriasis. Few lesions showed self resolution over a period of 6-12 weeks. Histopathology of the lesion confirmed it to be Keratoacanthoma. We believe the most likely etiologic factors for the multiple KAs in our patient could be a genetic susceptibility stimulated by multiple causes.