Open AccessImmunohistochemical detection of P53 and Mdm2 in vitiligo
Author(s) -
Ola Ahmed Bakry,
M. A. Hammam,
Moshira M. Abd-El Wahed
Publication year - 2012
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/2229-5178.101812
Subject(s) - vitiligo , medicine , dermatology , skin cancer , basal cell carcinoma , pigmentation disorder , immunohistochemistry , pathology , melanoma , h&e stain , cancer , basal cell , cancer research
Vitiligo is a common depigmented skin disorder that is caused by selective destruction of melanocytes. It is generally accepted that the main function of melanin resides in the protection of skin cells against the deleterious effect of ultraviolet rays (UVRs). Association of vitiligo and skin cancer has been a subject of controversy. Occurrence of skin cancer in long-lasting vitiligo is rare despite multiple evidences of DNA damage in vitiliginous skin.