Open AccessCorrelation of enhanced oxidative stress with altered thyroid profile: Probable role in spontaneous abortion
Author(s) -
Ravinder Kaur,
Kapil Gupta,
Harpreet Kaur
Publication year - 2017
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/2229-516x.198514
Subject(s) - miscarriage , medicine , malondialdehyde , lipid peroxidation , oxidative stress , endocrinology , abortion , pregnancy , thyroid function , hormone , body mass index , biology , genetics
Spontaneous abortion or miscarriage is defined as the loss of a clinically recognized pregnancy that occurs before 20 weeks of gestational age. Changes in thyroid function can impact greatly on reproductive function before, during, and after conception. Oxidative stress affects both implantation and early embryo development by modifying the key of transcription. Malondialdehyde (MDA) is a major breakdown product of split off from lipid peroxidation. Superoxide dismutase (SOD) is responsible for detoxification of superoxide anion and required for normal health and reproduction.