Open AccessIsolated extracranial intraosseous metastasis of an intracranial meningioma following bevacizumab therapy: Case report and review of the literature
Author(s) -
Debraj Mukherjee,
Jethro Hu,
Ray Chu
Publication year - 2018
Publication title -
asian journal of neurosurgery
Language(s) - English
Resource type - Journals
ISSN - 2248-9614
DOI - 10.4103/1793-5482.185057
Subject(s) - medicine , meningioma , bevacizumab , metastasis , radiology , intracranial tumor , pathological , radiation therapy , surgery , cancer , pathology , chemotherapy
Meningiomas account for a significant proportion of all primary intracranial tumors; distant metastasis is quite rare. We report a patient with resected, atypical meningioma. The patient's clinical course over 5 years included two craniotomies, a course of radiation, and a shortened course of bevacizumab. Only 5 months after starting bevacizumab, the patient developed an isolated left clavicular pathological fracture attributable to metastatic anaplastic meningioma. This constitutes the first report of meningioma with isolated extracranial intraosseous metastasis in the modern English literature and highlights concerns associated with the use of anti-angiogenic agents in promoting more invasive tumor phenotypes upon disease recurrence.