Open AccessLevetiracetam seizure prophylaxis in craniotomy patients at high risk for postoperative seizures
Author(s) -
Sankalp Gokhale,
Shazia Khan,
Abhishek Agrawal,
Allan H. Friedman,
David L. McDonagh
Publication year - 2013
Publication title -
asian journal of neurosurgery
Language(s) - English
Resource type - Journals
ISSN - 2248-9614
DOI - 10.4103/1793-5482.125658
Subject(s) - medicine , levetiracetam , anesthesia , somnolence , epilepsy , craniotomy , surgery , incidence (geometry) , retrospective cohort study , adverse effect , physics , psychiatry , optics
The risk of developing immediate postoperative seizures in patients undergoing supratentorial brain tumor surgery without anti-epileptic drug (AED) prophylaxis is 15-20%. Patients who present with pre-operative seizures and patients with supratentorial meningioma or supratentorial low grade gliomas are at significantly higher risk. There is little data on the efficacy of levetiracetam as a prophylactic AED in the immediate postoperative period (within 7 days of surgery) in these patients.