Open AccessSynthesis, characterization, molecular docking, antimalarial, and antiproliferative activities of benzyloxy-4-oxopyridin benzoate derivatives
Author(s) -
Marjan Mohebi,
Neda Fayazi,
Somayeh Esmaeili,
Mahboubeh Rostami,
Fariborz Bagheri,
Alireza Aliabadi,
Parvin Asadi,
Lotfollah Saghaie
Publication year - 2022
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.343079
Subject(s) - chemistry , heme , docking (animal) , cytotoxicity , hemozoin , stereochemistry , mtt assay , ic50 , combinatorial chemistry , in vitro , antimalarial agent , cell culture , biochemistry , plasmodium falciparum , enzyme , malaria , biology , medicine , nursing , genetics , immunology
Malaria and cancer are two major health issues affecting millions of lives annually. Maltol complexes and derivatives have been extensively investigated as chemotherapeutic and antimalarial activities. In this study, the design, synthesis, biological activities, and docking study of a novel series of pyridinones derivatives were reported.