Open AccessAnti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
Author(s) -
Azadeh Motavallian,
Ehsan Zamani,
Saba Bouzari,
Farzam Rezaeyan,
Paridokht Karimian,
Mehdi Evazalipour
Publication year - 2022
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.329924
Subject(s) - colitis , medicine , pregabalin , myeloperoxidase , inflammatory bowel disease , tumor necrosis factor alpha , gastroenterology , acetic acid , pharmacology , inflammation , necrosis , disease , anesthesia , chemistry , biochemistry
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease characterized by the inflammation of the intestine. The available medicinal treatments for IBD are not efficacious enough since they exert various adverse effects. Therefore, the search for new therapeutic agents should be continued. The present study aimed to assess the anti-inflammatory effects of pregabalin on acetic acid-induced colitis in rats.