Open AccessAnti-inflammatory effects of saxagliptin and vildagliptin against doxorubicin-induced nephrotoxicity in rats: attenuation of NLRP3 inflammasome up-regulation and tubulo-interstitial injury
Author(s) -
Rasha E. Mostafa,
Azza Hassan Morsi,
Gihan F. Asaad
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.323920
Subject(s) - nephrotoxicity , inflammasome , pharmacology , vildagliptin , inflammation , nitric oxide synthase , medicine , kidney , tumor necrosis factor alpha , oxidative stress , nitric oxide , chemistry , endocrinology , metformin , diabetes mellitus
The clinical use of the chemotherapeutic drug, doxorubicin (DXR), is significantly limited by its extensive multi-organ toxicity. Dipeptidyl peptidase-4 (DPP4) is over-expressed in oxidative stress, inflammation and apoptosis. DPP4 inhibitors have proven pleiotropic effects. The study investigates the protective effects of some DDP4 inhibitors; namely, saxagliptin (SAX) and vildagliptin (VIL) against DXR-induced nephrotoxicity in rats.