Open AccessDesign, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase
Author(s) -
Motahareh Hassanzadeh,
Farshid Hassanzadeh,
Ghadam Ali Khodarahmi,
Mahbobe Rostami,
Fateme Azimi,
Hamid Nadri,
Farshad Homayouni Moghadam
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.323915
Subject(s) - acetylcholinesterase , chemistry , rivastigmine , donepezil , isoindoline , cholinesterase , aché , neuroprotection , butyrylcholinesterase , pharmacology , ic50 , acetylcholine , stereochemistry , enzyme , biochemistry , in vitro , dementia , medicinal chemistry , medicine , disease
Alzheimer's disease is considered one of the lead causes of elderly death around the world. A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer's disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects.