Open AccessAnti-inflammatory effect of Perilla frutescens seed oil rich in omega-3 fatty acid on dextran sodium sulfate-induced colitis in mice
Author(s) -
Napapan Kangwan,
Komsak Pintha,
Chakkrit Khanaree,
Sarawut Kongkarnka,
Teera Chewonarin,
Maitree Suttajit
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.323913
Subject(s) - colitis , ulcerative colitis , inflammatory bowel disease , proinflammatory cytokine , omega 3 fatty acid , inflammation , medicine , fatty acid , perilla frutescens , chemistry , gastroenterology , immunology , pharmacology , polyunsaturated fatty acid , biochemistry , disease , docosahexaenoic acid
Ulcerative colitis is a chronic inflammatory bowel disease that involves diffused inflammation of the large intestine. Omega-3 fatty acid (FA) has been known to regulate the inflammatory response associated with ulcerative colitis pathogenesis. Perilla frutescens is a valuable source of omega-3 FA and α-linolenic acid (ALA) contained in its seed oil. Therefore, the aim of this study was to evaluate the anti-inflammatory effect of Perilla seed oil (PSO) on colitis induced by dextran sulfate sodium (DSS) in a mouse model.