Open AccessSynthesis and cytotoxic evaluation of some novel 3-[2-(2-phenyl-thiazol-4-yl)-ethyl] -3H-pyrido [2,3-d]pyrimidin-4-one derivatives
Author(s) -
Marzieh Rahmani Khajouei,
Ghadamali Khodarahmi,
Aram Ghaderi
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.323912
Subject(s) - thiazole , hela , chemistry , cytotoxic t cell , cytotoxicity , acetic anhydride , combinatorial chemistry , acetic acid , stereochemistry , mtt assay , organic chemistry , in vitro , biochemistry , catalysis
Pyridopyrimidine and its derivatives have a variety of chemical and biological significances. Thiazole-containing compounds have also been reported to have a wide range of biological activities. Due to the valuable cytotoxic effects of both thiazole and pyridopyrimidinone derivatives, a series of pyridopyrimidinone-thiazole hybrids were synthesized in the present study.