Open AccessPreparation and characterization of Eudragit L 100-55/chitosan enteric nanoparticles containing omeprazole using general factorial design: in vitro/in vivo study
Author(s) -
Mahboubeh Rezazadeh,
Reza Safaran,
Mohsen Minaiyan,
Abolfazl Mostafavi
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.319574
Subject(s) - coacervate , omeprazole , in vivo , chitosan , chemistry , zeta potential , nanoparticle , factorial experiment , in vitro , ex vivo , nuclear chemistry , particle size , chromatography , pharmacology , nanotechnology , materials science , biochemistry , medicine , mathematics , statistics , microbiology and biotechnology , biology
Omeprazole (OMP) is broadly used for the treatment of gastroesophageal reflux and other acid-related diseases. The current study aimed to prepare enteric-coated nanoparticles containing OMP to achieve a stable powder formulation easily prescribed in children.