Open AccessMutual assistance of nucleus accumbens cannabinoid receptor-1 and orexin receptor-2 in response to nicotine: a single-unit study
Author(s) -
Reza Fartootzadeh,
Hojjatallah Alaei,
Parham Reisi
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.310524
Subject(s) - am251 , nicotine , nucleus accumbens , chemistry , pharmacology , microinjection , cannabinoid , cannabinoid receptor , antagonist , orexin , endocannabinoid system , receptor , endocrinology , medicine , neuropeptide , biochemistry
The nucleus accumbens (NAc) express both orexin-2 receptor (OX2R) and cannabinoid receptor type 1 (CB1R). Orexin and cannabinoid regulate the addictive properties of nicotine. In this study, the effect of the CB1R blockade on the electrical activity of NAc neurons in response to nicotine, and its probable interaction with the OX2R in this event, within this area, were examined via the single-unit recording.