Open AccessDevelopment and characterization of a nano-drug delivery system containing vasaka phospholipid complex to improve bioavailability using quality by design approach
Author(s) -
S. Nandhini,
K. Ilango
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.305193
Subject(s) - bioavailability , particle size , zeta potential , solubility , factorial experiment , materials science , pulmonary surfactant , absorption (acoustics) , drug delivery , chemistry , chromatography , pharmacology , nanotechnology , nanoparticle , medicine , mathematics , organic chemistry , composite material , biochemistry , statistics
Vasicine is a potential bronchodilator and can be used for the effective management of asthma and bronchitis. It has low absorption in the gastrointestinal tract due to its poor solubility thereby low bioavailability. The objective of this research was to develop a novel drug delivery system of vasaka extract to improve its bioavailability by enhancing the solubility and absorption of vasicine.