Open AccessComparison of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration alone in reducing amphotericin B nephrotoxicity: a randomized clinical trial
Author(s) -
Iman Karimzadeh,
Asma Sepehr-Sobhani,
Mohammad Javad Khoshnoud,
Mohammad Mahdi Sagheb,
Reza Vejdani,
Atefeh Jalali,
Motahareh Mahi-Birjand
Publication year - 2020
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.301343
Subject(s) - sodium bicarbonate , nephrotoxicity , saline , sodium , medicine , bicarbonate , hypokalemia , chemistry , pharmacology , anesthesia , kidney , organic chemistry
The most important adverse reaction of amphotericin B (AmB) is nephrotoxicity. The aim of this study was to assess the potential effectiveness of intravenous saline + sodium bicarbonate versus intravenous sodium chloride hydration in preventing or attenuating AmB nephrotoxicity.