Open AccessEvaluation of long-chain acyl-coenzyme A synthetase 4 (ACSL4) expression in human breast cancer
Author(s) -
Negar Dinarvand,
Hossein Khanahmad,
Sayyed Mohammadreza Hakimian,
Abdolkarim Sheikhi,
Bahman Rashidi,
Morteza Pourfarzam
Publication year - 2020
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.278714
Subject(s) - immunohistochemistry , lipid metabolism , cancer , biology , breast cancer , staining , biochemistry , chemistry , immunology , genetics
Breast cancer (BC) is one of the major causes of female cancer-related death. It has recently been demonstrated that metabolic reprogramming including alteration in lipid metabolism is indicated in various types of cancer. The enzymes of the acyl-coenzyme A synthetase long-chain family (ACSLs) are responsible for converting fatty acids to their corresponding fatty acyl-coenzyme A esters which are essential for some lipid metabolism pathways. ACSL4 is one of the isoforms of ACSLs and has a marked preference for arachidonic and eicosapentaenoic acids. The objective of this study was to evaluate ACSL4 expression, its prognostic significance, and its correlation with p53 tumor suppressor in BC patients.