Open AccessGorlin-Goltz syndrome
Author(s) -
Priya Joshi,
Vijay Deshmukh,
Someshwar Golgire
Publication year - 2012
Publication title -
dental research journal.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.334
H-Index - 17
eISSN - 2008-0255
pISSN - 1735-3327
DOI - 10.4103/1735-3327.92963
Subject(s) - nevoid basal cell carcinoma syndrome , basal cell nevus syndrome , medicine , falx cerebri , pathology , rare disease , disease , basal cell , basal cell carcinoma
Gorlin-Goltz syndrome is an uncommon autosomal dominant inherited disorder, which is characterized by multiple odontogenic Keratocysts and basal cell carcinomas, skeletal, dental, ophthalmic, and neurological abnormalities, intracranial ectopic calcifications of the falx cerebri, and facial dysmorphism. Pathogenesis of the syndrome is attributed to abnormalities in the long arm of chromosome 9 (q22.3-q31) and loss or mutations of human patched gene (PTCH1 gene). Diagnosis is based upon established major and minor clinical and radiological criteria and ideally confirmed by deoxyribo nucleic acid analysis. We report a case of a 9-year-old girl presenting with three major and one minor feature of Gorlin-Goltz syndrome. Radiologic findings of the syndrome are easily identifiable on Orthopantomogram, chest X-ray, and Computed tomography scans. These investigations prompt an early verification of the disease, which is very important to prevent recurrence and better survival rates from the coexistent diseases.