Open AccessBrain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration
Author(s) -
Jin-Wook Kim,
Sueun Lee,
Sohi Kang,
Sung Hoon Kim,
Jong-Choon Kim,
Miyoung Yang,
Changjong Moon
Publication year - 2017
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.217353
Subject(s) - neuroregeneration , neurodegeneration , neuroscience , neurotoxicity , excitotoxicity , medicine , gabaergic , neuroinflammation , neuroplasticity , neurology , neuroprotection , biology , disease , pathology , glutamate receptor , receptor , toxicity , inhibitory postsynaptic potential
Neurotoxicity induced by stress, radiation, chemicals, or metabolic diseases, is commonly associated with excitotoxicity, oxidative stress, and neuroinflammation. The pathological process of neurotoxicity induces neuronal death, interrupts synaptic plasticity in the brain, and is similar to that of diverse neurodegenerative diseases. Animal models of neurotoxicity have revealed that clinical symptoms and brain lesions can recover over time via neuroregenerative processes. Specifically, brain-derived neurotropic factor (BDNF) and gamma-aminobutyric acid (GABA)-ergic transmission are related to both neurodegeneration and neuroregeneration. This review summarizes the accumulating evidences that suggest a pathogenic role of BDNF and GABAergic transmission, their underlying mechanisms, and the relationship between BDNF and GABA in neurodegeneration and neuroregeneration. This review will provide a comprehensive overview of the underlying mechanisms of neuroregeneration that may help in developing potential strategies for pharmacotherapeutic approaches to treat neurotoxicity and neurodegenerative disease.